I have always used EXRs (OctaneEXR, variety of compressions and floats) with AE in the past years without much issue. However recently I was getting terrible memory overuse in AE and it took me an age to work out that it was because of EXRs. Not noticed in short jobs but when you have around a mins worth of 1080p content you will start to see your machine (win 10) overuse memory (killing my 64G). I have been told my test files were ok on the mac. I have resorted to PNG32bit for the time being without the issue happening. I have wasted many days trying to figure out what is going on, for example the same EXR seq as an AE project brought into Premiere is 100% - no issues. Yet again Adobe isnt testing things as well as they should be, EXR is an important format to support. Hope this helps someone.